Which statement about ACE inhibitors or ARBs in diabetic nephropathy is false?

• A. They Reduce Intraglomerular Pressure
• B. They Decrease Proteinuria
• C. They Slow Progression
• D. They Cure Diabetic Nephropathy

Answer: (D)

The key idea is that blocking the RAAS with ACE inhibitors or ARBs protects the kidney by lowering pressure inside the glomeruli, which reduces protein leakage and slows the march of diabetic nephropathy. Angiotensin II tends to constrict the efferent arteriole, raising intraglomerular pressure; by inhibiting this effect, these medications lower the pressure, lessen albuminuria, and slow progression toward kidney failure. However, they do not reverse established structural damage or cure the disease—the nephropathy can still progress despite treatment. So the statement that they cure diabetic nephropathy is false, while their ability to reduce proteinuria, lower intraglomerular pressure, and slow progression is true.