Besides the bladder, urothelial carcinoma can also occur in which locations?

• A. Renal pelvis or ureter
• B. Brain
• C. Lungs
• D. Spleen

Answer: (A)

Urothelial carcinoma comes from the urothelium, the transitional epithelium lining the urinary tract. While the bladder is the most common site, cancers can also arise in other urothelium-lined areas, particularly the renal pelvis and the ureter—sites of upper tract urothelial carcinoma. The brain, lungs, and spleen don’t contain urothelium, so primary urothelial tumors don’t originate there ( though cancer can spread to distant organs, that’s different from the primary site).