Any degenerative kidney disease causing nephritic syndrome without inflammation.

• A. Nephrosis
• B. Nephrotic syndrome
• C. Nephritis
• D. Pyelonephritis

Answer: (D)

Nephritic syndrome is defined by inflammation of the glomeruli, which produces hematuria, red blood cell casts, some protein in the urine, and often high blood pressure and kidney dysfunction. Because inflammation is part of its identity, the idea of a degenerative kidney disease that causes nephritic syndrome without any inflammation doesn’t fit the typical clinical picture.

Among degenerative, noninflammatory kidney diseases, the pattern is nephrotic syndrome—heavy proteinuria, edema, low albumin, and usually high cholesterol. This condition reflects a noninflammatory glomerular lesion (nephrosis) rather than inflammation, so it aligns with a nephrotic rather than nephritic presentation.

In contrast, pyelonephritis is an inflammatory infection of the kidney, which again involves inflammation and does not describe nephritic syndrome without inflammation.

So, conceptually, the scenario described isn’t consistent with how nephritic syndrome develops. The noninflammatory, degenerative kidney disease points toward nephrotic syndrome (nephrosis) rather than nephritic syndrome.